![]() Raters identified the correct chronologic order in 53 of 64 (83%) of responses. ![]() ![]() Following a pilot, we tested the inter-rater reliability of the CGA using eight cases rated by eight clinicians. They were asked to determine the chronologic order and, based on that response, rate global clinical change using a seven-point scale (Much Worse, Worse, Minimally Worse, No Change, Minimally Improved, Improved, Much Improved). The chronologic order of each set was blinded and presented to clinicians familiar with overgrowth disorders. We gathered paired serial photographs and radiographs obtained at 12-to-36-month intervals from our natural history study of Proteus syndrome. The Clinical Gestalt Assessment (CGA) aims to evaluate change over time in this phenotypically diverse disorder. To address these, we designed a global clinical assessment for Proteus syndrome, a rare mosaic overgrowth disorder. The heterogenous phenotype and difficult to quantity features of Proteus syndrome present challenges to measuring clinical outcomes. ![]() ![]() Clinical outcome assessments are important tools for measuring the natural history of disease and efficacy of an intervention. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |